News Summary
As the Indianapolis Colts gear up for their game against the Los Angeles Rams, they confront significant injury issues with key players sidelined. The team hopes to achieve a 4-0 record but faces setbacks, including injuries to Alec Pierce and Kenny Moore II. Despite some players returning to practice, the Colts’ depth is put to the test, and they have signed veteran players to bolster their squad. The outcome of the upcoming game hinges on how well the Colts manage these injury challenges.
Indianapolis Faces Injury Challenges Ahead of Week 4 Matchup Against the Los Angeles Rams
Indianapolis, IN — As the Indianapolis Colts prepare for their upcoming game against the Los Angeles Rams, team officials are facing significant injury concerns that could impact their performance. The game is scheduled for Sunday, September 28, 2025, at SoFi Stadium in Los Angeles. The Colts are aiming to reach a 4-0 record for the first time since 2009, but injuries among key players threaten this goal.
Key Players Dealing with Injuries
Several important players are currently sidelined or limited due to injuries as the team approaches their Week 4 contest. Wide receiver Alec Pierce is out with a concussion, while cornerback Kenny Moore II is unavailable because of an Achilles injury. Defensive tackle DeForest Buckner missed practice due to a back issue but returned to practice on Thursday, indicating progress in his recovery.
Other players face injury setbacks that could affect the Colts’ lineup. Guard Matt Goncalves was seen in a walking boot due to a toe injury and is out for the game, while punter Rigoberto Sanchez is out for personal reasons. Despite these challenges, some players are participating fully in practice, providing the team with some optimism regarding their health.
Player Participation and Practice Updates
Wide receiver Michael Pittman Jr. participated fully in practice, giving the team a reliable target on offense. Tight end Tyler Warren, who earned NFL Rookie of the Week honors for Week 2, returned after missing one day due to a toe injury. Running back Jonathan Taylor remains active and practices regularly, maintaining his role in the team’s plans. Conversely, quarterback Daniel Jones did not practice Thursday and is expected to miss multiple games, though his status is being closely monitored.
Defensive Adjustments and Signings
Team leadership continues to emphasize the importance of a “next man up” mentality amid Moore’s injury. The Colts have signed veteran cornerback Mike Hilton to their practice squad to strengthen their secondary. Hilton’s previous experience under Defensive Coordinator Lou Anarumo during their time in Cincinnati provides him with familiarity that could benefit the defense.
Additionally, Mekhi Blackmon, acquired via trade with the Minnesota Vikings, is anticipated to step into a larger role and fill the void left by Moore’s absence. The linebacker and defensive line units are also trying to adapt with players including Tyquan Lewis and DeForest Buckner participating in practice.
Practice Session and Future Outlook
The Colts held their practice session at the Indiana Farm Bureau Football Center, where players like tight end Drew Ogletree, defensive linemen Tyquan Lewis, and DeForest Buckner showcased their abilities. The defensive squad, featuring players such as Charvarius Ward and Camryn Bynum, remains poised to execute against the Rams despite injury concerns.
Team officials continue to monitor the health status of multiple players as they finalize their strategies for Sunday’s game, aiming to optimize their chances of victory while navigating the injury landscape.
Summary
The Indianapolis Colts are facing multiple injury-related challenges as they prepare for their Week 4 game against the Los Angeles Rams. Key players like Alec Pierce and Kenny Moore II are out, while others such as DeForest Buckner and Tyler Warren are nearing full participation. The team has responded by signing veteran players to bolster their depth and remains focused on how best to proceed. The outcome of the game could hinge on how well the team manages its injury issues and the performance of available players on game day.
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Additional Resources
- Colts Practice Notebook
- Sports Illustrated: Colts Starters Trending Downward
- IndyStar: Colts Injury Report
- Colts Wire: Roster Moves
- Reuters: Titans QB Practice Update
- Wikipedia: Indianapolis Colts

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