News Summary
The Indianapolis Colts will face the Arizona Cardinals in a highly anticipated Week 6 matchup at Lucas Oil Stadium. The two teams have a close series history, with the Colts leading 9-8 in their previous encounters. The Colts, boasting a strong 4-1 record, look to capitalize on their home advantage, while the Cardinals aim to rebound from recent losses. Injury updates on key players like Kyler Murray will be crucial as both teams seek to improve their standings. Tune in on Fox for live coverage.
Indianapolis, IN – NFL Week 6 Features Colts versus Cardinals at Lucas Oil Stadium
The Indianapolis Colts will host the Arizona Cardinals on Sunday, October 12, 2025, for their Week 6 matchup at Lucas Oil Stadium. This game marks the 18th regular-season meeting between the two teams, with the Colts holding a narrow series lead of 9 wins to 8 losses. The game is scheduled to kick off at 1 p.m. Eastern Time and will be broadcast on Fox, with coverage provided by Kevin Kugler, Daryl Johnston, and Allison Williams.
Series History and Recent Matchups
The Colts and Cardinals have faced each other 17 times in regular-season play, with the previous game played in Week 16 of 2021. In that contest, the Colts emerged victorious with a 22-16 win on Christmas Day. The series has been closely contested over the years, with the Colts currently holding a slight edge.
Current Records and Standings
The Colts enter the game with a strong 4-1 record, tying them for first place in the AFC South division alongside the Jacksonville Jaguars. They have demonstrated offensive efficiency, highlighted by a commanding 40-6 win against the Las Vegas Raiders earlier this season. Conversely, the Arizona Cardinals have a 2-3 record and sit in the middle of the standings but have shown resilience, having led in the fourth quarter of every game they’ve played this season. Despite that, the team has lost three contests by a total of only five points, indicating competitive performance despite setbacks.
Key Players and Injury Updates
The Cardinals quarterback, Kyler Murray, is listed as questionable for the game due to a foot injury sustained last week. However, he has returned to practice, suggesting he may play on Sunday. The game’s outcome could hinge on his participation and overall health.
Team Performance and Defensive Capabilities
Both teams boast solid defensive ranks. The Colts are ranked fifth in expected points added per play on defense, indicating a strong defensive unit capable of limiting opponents’ scoring opportunities. The Cardinals, despite their record, have maintained competitive play by leading in the fourth quarter of all their games this season. Their close losses highlight their ability to stay competitive late in games, though they have yet to find consistent success.
Additional Game Information
Complete gameday details are available at Colts.com/Gameday, and tickets for the game can be purchased through Ticketmaster.com. Fans can also stream live local and primetime games via NFL+, which is available starting at $6.99 per month. Local radio coverage in Indianapolis is provided on stations 93.5 / 107.5 The Fan, 97.1 HANK, and the Ascension St. Vincent Radio Network. Fans are advised to check local TV listings for broadcast options, as network coverage will be determined by the NFL’s television partners.
Summary
In sum, the Week 6 matchup at Lucas Oil Stadium features an evenly matched series between the Colts and Cardinals, with both teams aiming to improve their standings. The Colts aim to continue their winning streak and capitalize on their home-field advantage, while the Cardinals look to bounce back from prior losses and leverage their competitiveness in the fourth quarter. The game promises to be an intriguing contest with playoff implications as the season progresses.
Frequently Asked Questions
Where is the game played? The game is played at Lucas Oil Stadium in Indianapolis.
What time does the game start? The game kicks off at 1 p.m. Eastern Time on Sunday, October 12, 2025.
What is the current record of the Indianapolis Colts? The Colts currently have a 4-1 record.
What is the current record of the Arizona Cardinals? The Cardinals are at 2-3.
Has the Colts and Cardinals played before? Yes, they have faced each other 17 times before, with their last meeting in Week 16 of 2021, which the Colts won 22-16.
Who are the TV broadcasters for the game? Coverage will be on Fox with Kevin Kugler, Daryl Johnston, and Allison Williams.
Are there options to stream or listen to the game? Yes, fans can stream live local and primetime games via NFL+, starting at $6.99/month. Local radio coverage is available on stations 93.5 / 107.5 The Fan, 97.1 HANK, and the Ascension St. Vincent Radio Network.
Will Kyler Murray play? Murray is listed as questionable due to a foot injury but has returned to practice, leaving his participation uncertain.
Deeper Dive: News & Info About This Topic
HERE Resources
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Additional Resources
- Horseshoe Heroes
- Pickswise
- IndyStar
- Covers
- A to Z Sports
- Wikipedia: National Football League
- Google Search: Indianapolis Colts
- Google Scholar: Indianapolis Colts Arizona Cardinals 2025
- Encyclopedia Britannica: National Football League
- Google News: Colts Cardinals Week 6
Author: STAFF HERE INDIANAPOLIS WRITER
The INDIANAPOLIS STAFF WRITER represents the experienced team at HEREIndianapolis.com, your go-to source for actionable local news and information in Indianapolis, Marion County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as the Indianapolis 500, Indy Jazz Fest, and the Indiana State Fair. Our coverage extends to key organizations like the Indy Chamber and Visit Indy, plus leading businesses in motorsports and healthcare that power the local economy such as Indianapolis Motor Speedway and IU Health. As part of the broader HERE network, we provide comprehensive, credible insights into Indiana's dynamic landscape.
