Indianapolis, December 25, 2025
The San Francisco 49ers have secured a playoff spot following a dominant 48-27 win over the Indianapolis Colts during Monday Night Football. The game was highlighted by linebacker Dee Winters’ 74-yard interception return for a touchdown and quarterback Brock Purdy’s record-tying five touchdown passes. With strong contributions from rookie defensive linemen, the team looks ahead to their next game against the Chicago Bears.
San Francisco 49ers Clinch Playoff Berth with 48-27 Win
Indianapolis, IN – The San Francisco 49ers secured a playoff spot with an impressive 48-27 victory over the Indianapolis Colts during Monday Night Football. Linebacker Dee Winters played a pivotal role by sealing the win with a remarkable 74-yard interception return for a touchdown in the fourth quarter.
Key Moments
- Dee Winters’ Game-Sealing Play: With under four minutes remaining, Winters intercepted a pass from Colts quarterback Philip Rivers that was intended for tight end Tyler Warren and returned it 74 yards for a touchdown, effectively ending the game.
- Brock Purdy’s Historic Performance: Quarterback Brock Purdy also shone during the matchup, throwing five touchdown passes—tying a franchise record for the most in a single game. He completed 25 of 34 attempts for 295 yards.
- Rookie Defensive Contributions: Rookie defensive linemen C.J. West and Alfred Collins each made their mark with their first NFL sacks, showing that the team’s future looks bright.
Game Overview
The 49ers showcased a dominating offensive effort, failing to punt for the second consecutive game. Purdy’s accurate passing and the offense’s ability to capitalize on opportunities were crucial to the team’s impressive scoring. While the defense allowed over 170 passing yards and two touchdowns in the first half, they tightened up in the second half, ultimately limiting the Colts to just 10 points. This strong defensive response, highlighted by the rookies’ contributions, proved instrumental in the team’s success.
Looking Ahead
With this victory, the 49ers now focus on their upcoming challenge against the Chicago Bears at Levi’s Stadium. Their solid performances the past couple of weeks have generated momentum, which will be vital as they prepare for the rigorous demands of the playoffs.
Frequently Asked Questions
What was the final score of the 49ers vs. Colts game?
The San Francisco 49ers defeated the Indianapolis Colts with a final score of 48-27.
Who scored the game-sealing touchdown for the 49ers?
Linebacker Dee Winters secured the win with a 74-yard interception return for a touchdown in the fourth quarter.
How did Brock Purdy perform in the game?
Quarterback Brock Purdy threw five touchdown passes, tying a franchise record for the most in a single game, and completed 25 of 34 passes for 295 yards.
Which rookies made significant contributions in the game?
Rookie defensive linemen C.J. West and Alfred Collins each recorded their first NFL sacks during the game.
What is the 49ers’ next game after the win against the Colts?
The 49ers will face the Chicago Bears at Levi’s Stadium in their next game, aiming to build on their momentum as they prepare for the playoffs.
Key Features of the Game
| Feature | Details |
|---|---|
| Final Score | 49ers 48, Colts 27 |
| Game-Sealing Play | Dee Winters’ 74-yard interception return for a touchdown |
| Brock Purdy’s Performance | Five touchdown passes, 25 of 34 completions, 295 yards |
| Rookie Contributions | C.J. West and Alfred Collins each recorded their first NFL sacks |
| Next Opponent | Chicago Bears at Levi’s Stadium |
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Author: STAFF HERE INDIANAPOLIS WRITER
The INDIANAPOLIS STAFF WRITER represents the experienced team at HEREIndianapolis.com, your go-to source for actionable local news and information in Indianapolis, Marion County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as the Indianapolis 500, Indy Jazz Fest, and the Indiana State Fair. Our coverage extends to key organizations like the Indy Chamber and Visit Indy, plus leading businesses in motorsports and healthcare that power the local economy such as Indianapolis Motor Speedway and IU Health. As part of the broader HERE network, we provide comprehensive, credible insights into Indiana's dynamic landscape.
