Indianapolis, January 11, 2026
The San Francisco 49ers secured a dominant 48-27 victory over the Indianapolis Colts at Lucas Oil Stadium, marking the Colts’ fifth consecutive loss. Quarterback Brock Purdy shone with five touchdown passes, while the Colts struggled defensively, allowing significant gains. The Colts now face a critical juncture in their season as they aim to secure playoff positioning in their upcoming games.
Indianapolis, IN – San Francisco 49ers Secure 48-27 Victory Over Colts on Monday Night Football
On December 22, 2025, the San Francisco 49ers defeated the Indianapolis Colts 48-27 at Lucas Oil Stadium, marking the Colts’ fifth consecutive loss.
Key Performances
49ers quarterback Brock Purdy delivered an exceptional performance, completing 25 of 34 passes for 295 yards and five touchdowns, tying a franchise record for most touchdown passes in a single game. Tight end George Kittle led the receiving corps with seven receptions for 115 yards and a touchdown.
Colts’ Offensive Highlights
Colts quarterback Philip Rivers, in his second game back after five years of retirement, completed 23 of 35 passes for 277 yards and two touchdowns. Wide receiver Alec Pierce caught all four of his targets for 86 yards and two touchdowns. Running back Jonathan Taylor added a rushing touchdown, contributing to the team’s 27 points.
Defensive Struggles
The Colts’ defense faced significant challenges, allowing 441 yards of total offense and five touchdowns. Linebacker Zaire Franklin acknowledged the team’s shortcomings, stating the team was dominated during the game.
Injury Updates
Prior to the game, the 49ers announced that wide receiver Ricky Pearsall would miss the matchup due to a knee injury sustained the previous week. The Colts’ final injury report listed cornerback Sauce Gardner as out with a calf injury, while quarterback Anthony Richardson was also out due to an eye injury.
Looking Ahead
The Colts now face a critical stretch to close the regular season, needing victories in their final two games to remain in playoff contention. Their next matchup is against the Jacksonville Jaguars, who clinched a playoff berth with the Colts’ loss.
Conclusion
This loss continues to underscore a troubling trend for the Colts this season, as they struggle to maintain both offensive and defensive consistency. Local fans will be hoping for a turnaround in the final stretch, as their team competes for the playoff spot. Supporting local sports and community engagement can truly fortify the spirit of Indianapolis, enhancing the vibrancy of this city.
Frequently Asked Questions
What was the final score of the Colts vs. 49ers game?
The San Francisco 49ers defeated the Indianapolis Colts 48-27 on December 22, 2025.
Who were the standout players in the game?
49ers quarterback Brock Purdy threw for 295 yards and five touchdowns, while tight end George Kittle had seven receptions for 115 yards and a touchdown. For the Colts, quarterback Philip Rivers completed 23 of 35 passes for 277 yards and two touchdowns, and wide receiver Alec Pierce caught four passes for 86 yards and two touchdowns.
What were the injury updates for the game?
Prior to the game, the 49ers announced that wide receiver Ricky Pearsall would miss the matchup due to a knee injury. The Colts’ final injury report listed cornerback Sauce Gardner as out with a calf injury, and quarterback Anthony Richardson was also out due to an eye injury.
What does this loss mean for the Colts’ playoff chances?
The Colts now face a critical stretch to close the regular season, needing victories in their final two games to remain in playoff contention.
| Feature | Details |
|---|---|
| Final Score | 49ers 48, Colts 27 |
| Standout Players | Brock Purdy (49ers QB): 295 yards, 5 TDs; George Kittle (49ers TE): 7 receptions, 115 yards, 1 TD; Philip Rivers (Colts QB): 277 yards, 2 TDs; Alec Pierce (Colts WR): 86 yards, 2 TDs |
| Injury Updates | Ricky Pearsall (49ers WR): Out with knee injury; Sauce Gardner (Colts CB): Out with calf injury; Anthony Richardson (Colts QB): Out with eye injury |
| Colts’ Playoff Implications | Colts need victories in final two games to remain in playoff contention |
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Author: STAFF HERE INDIANAPOLIS WRITER
The INDIANAPOLIS STAFF WRITER represents the experienced team at HEREIndianapolis.com, your go-to source for actionable local news and information in Indianapolis, Marion County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as the Indianapolis 500, Indy Jazz Fest, and the Indiana State Fair. Our coverage extends to key organizations like the Indy Chamber and Visit Indy, plus leading businesses in motorsports and healthcare that power the local economy such as Indianapolis Motor Speedway and IU Health. As part of the broader HERE network, we provide comprehensive, credible insights into Indiana's dynamic landscape.
