News Summary
The Arizona Cardinals are set to play the Indianapolis Colts at Lucas Oil Stadium, a crucial Week 6 game with playoff implications. Both teams are preparing for significant roster adjustments, especially with injuries affecting the Cardinals, including quarterback Kyler Murray. Meanwhile, the Colts aim to extend their winning streak as they lead their division. This matchup is critical as both teams navigate the mid-point of the NFL season.
Indianapolis, Indiana — The Arizona Cardinals are heading to Lucas Oil Stadium for a pivotal Week 6 NFL game against the Indianapolis Colts scheduled for Sunday, October 11, 2025. The matchup promises to be significant for both teams, as they approach the mid-point of the season.
Key Players Traveling for the Cardinals
The Cardinals’ traveling squad includes several notable players. Offensive lineman Will Hernandez (76), quarterback Kyler Murray (1), cornerback Kei’Trel Clark (13), defensively skilled Dalvin Tomlinson (94) and PJ Mustipher (79), as well as specialist long snapper Aaron Brewer (46). The team also includes kicker Chad Ryland (38), tight end Trey McBride (85), safety Budda Baker (3), wide receiver Simi Fehoko (80), linebacker Josh Sweat (10), quarterback Jacoby Brissett (7), running back Bam Knight (20), safety Dadrion “Rabbit” Taylor-Demerson (42), wide receivers Marvin Harrison Jr. (18) and Greg Dortch (4), along with defensive lineman Dante Stills (55).
Additional Defensive and Special Teams Players
Defensive lineman Will Johnson (0), Zachary Carter (90), cornerback Darren Hall (30), kicker Chad Ryland (38), wide receiver Xavier Weaver (89), defensive lineman Calais Campbell (93), linebacker Baron Browning (5), and linebacker Mack Wilson Sr. (2) are all part of the traveling roster, contributing to the team’s defensive and special teams units.
Injury Concerns and Playing Status
Heading into the game, the Cardinals face uncertainties regarding the health of quarterback Kyler Murray, who experienced a brief exit from Week 5 due to a foot injury. His playing status remains uncertain, prompting the preparation of backup quarterback Jacoby Brissett for what could be his first start against his former team, the Colts. The team has also reported injuries affecting other key players, including punter Blake Gillikin, who is nursing a back injury and could impact special teams performance in the game.
Team Records and Recent Performance
The Arizona Cardinals currently hold a 2-3 record after a tough loss to the Tennessee Titans in Week 5, where they were shut out 16-0 in the second half. The team is seeking to rebound after struggles on offense and is looking to shore up their performance heading into the remainder of the season.
The Colts’ Season and Matchup Significance
The Indianapolis Colts are having a successful start this season with a 4-1 record, under the leadership of head coach Shane Steichen. This game against the Cardinals is significant as it presents the Colts with an opportunity to extend their winning streak and strengthen their position in the AFC standings.
Player Moves and Roster Adjustments
In anticipation of the game, the Colts have elevated running back Ameer Abdullah and cornerback Cameron Mitchell to their active roster. These roster moves indicate strategic adjustments in response to injuries and team needs, aiming to reinforce their depth for the matchup against the Cardinals.
Additional Cardinals and Colts Participants
Beyond the core group, several other players traveled, including wide receivers Greg Dortch (4) and Xavier Weaver (89), defensive lineman Dante Stills (55), and linebacker Mack Wilson Sr. (2). The Colts’ roster increased with player elevations, ensuring they have options to compensate for injuries and maximize their competitive edge.
Summary
The Week 6 game between the Arizona Cardinals and Indianapolis Colts will be played at Lucas Oil Stadium in Indianapolis. The Cardinals are traveling with key players and are managing injury concerns, particularly regarding quarterback Kyler Murray. The Colts, leading their division with a 4-1 record, aim to capitalize on their advantageous season start. The outcome of this game could have implications for both teams’ season trajectories as they approach mid-season play.
FAQs
- Where is the game scheduled? The game is scheduled for Sunday, Oct. 11, 2025, at Lucas Oil Stadium in Indianapolis, IN.
- Which key Cardinals players are traveling? The traveling squad includes Will Hernandez, Kyler Murray, Kei’Trel Clark, Dalvin Tomlinson, PJ Mustipher, Aaron Brewer, Chad Ryland, Trey McBride, Budda Baker, Simi Fehoko, Josh Sweat, Jacoby Brissett, Bam Knight, Dadrion Taylor-Demerson, Marvin Harrison Jr., Greg Dortch, Dante Stills, Will Johnson, Zachary Carter, Darren Hall, Xavier Weaver, Calais Campbell, Baron Browning, and Mack Wilson Sr.
- What is the current record for each team? The Cardinals are 2-3, and the Colts are 4-1 heading into this game.
- What injury concerns are notable for the Cardinals? Kyler Murray’s foot injury has raised questions about his participation. Punter Blake Gillikin also has a back injury that may affect his ability to perform.
- Who are the notable new additions to the Colts’ roster? The Colts have elevated running back Ameer Abdullah and cornerback Cameron Mitchell to their active roster.
Deeper Dive: News & Info About This Topic
HERE Resources
Colts to Clash with Cardinals at Lucas Oil Stadium
Colts Dominate Raiders with Largest Win Since 2013
NFL Preseason Kickoff with Key Matchups
Additional Resources
- Newsweek: Cardinals Preparing for Bad Kyler Murray News
- Wikipedia: Arizona Cardinals
- SI.com: Colts Promote Two Active Roster for Cardinals Matchup
- Google Search: Indianapolis Colts
- NBC Sports: Cardinals at Colts Prediction and Betting Trends
- Google Scholar: Kyler Murray
- IndyStar: NFL Week 6 Predictions for Colts vs. Cardinals
- Encyclopedia Britannica: National Football League
- AZ Cardinals: Injury Report for Week 6 vs. Colts
- Google News: Arizona Cardinals vs Indianapolis Colts
Author: STAFF HERE INDIANAPOLIS WRITER
The INDIANAPOLIS STAFF WRITER represents the experienced team at HEREIndianapolis.com, your go-to source for actionable local news and information in Indianapolis, Marion County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as the Indianapolis 500, Indy Jazz Fest, and the Indiana State Fair. Our coverage extends to key organizations like the Indy Chamber and Visit Indy, plus leading businesses in motorsports and healthcare that power the local economy such as Indianapolis Motor Speedway and IU Health. As part of the broader HERE network, we provide comprehensive, credible insights into Indiana's dynamic landscape.
