News Summary
The Indianapolis Colts are set to face the Tennessee Titans in a crucial early-season matchup. With the Colts boasting an undefeated record of 2-0 and the Titans struggling at 0-2, the game at Nissan Stadium in Nashville will be pivotal. The Colts aim to maintain their momentum with strong performances from key players despite some injury concerns, while the Titans look to turn their season around amidst several injuries affecting their roster. Both teams will be eager to establish themselves in the AFC South.
Indianapolis, Indiana—Week 3 NFL Matchup Preview
The Indianapolis Colts are preparing for their upcoming game against the Tennessee Titans, scheduled to take place at Nissan Stadium in Nashville at 1 p.m. ET on Sunday, September 21, 2025. The game features a matchup between the Colts, who are unbeaten at 2-0, and the Titans, who are still searching for their first win of the season with a 0-2 record. This encounter is important for both teams as they look to build momentum early in the season.
Colts Come into the Game Undefeated
The Colts have made an impressive start to the 2025 season, capturing victories in their first two games for the first time since 2009. Their strong early performance has lots of attention, especially as they try to continue their winning streak against the Titans. This marks a significant milestone for the team, which aims to maintain its momentum in the face of adversity.
Challenges for the Tennessee Titans
The Titans are in a difficult position, holding an 0-2 record after losing their first two games. Added to their challenges are key injuries to several players that could impact their game plan and overall performance. The team’s injury list includes several starters listed as doubtful or limited in practice, which could further weaken their ability to compete effectively.
Injury Reports and Key Player Updates
Indianapolis Colts Injuries
- Wide Receiver Josh Downs (ankle) – did not practice on Wednesday
- Rookie Tight End Tyler Warren (toe) – did not practice on Wednesday
- Defensive End Laiatu Latu (hamstring) – limited participation
- Tackle Bernhard Raimann (illness) – limited participation
- Linebacker Austin Ajiake (throat) – full participation
- Running Back Tyler Goodson (elbow) – inactive for the first two games
- Cornerback Charvarius Ward (concussion) – full participation after missing Week 2
Tennessee Titans Injuries
- Tackle J.C. Latham (hip) – did not practice, remains sidelined
- Guard Kevin Zeitler (elbow) – did not practice, but has played in both games
- Cornerback L’Jarius Sneed (back) – did not practice
- Receiver Bryce Oliver (knee) – did not practice
- Nose Tackle T’Vondre Sweat – limited participation as he works to return from previous absence
Team Performance and Matchup Insights
The Colts’ offense is expected to lean heavily on Jonathan Taylor, who is likely to be a vital part of their strategy against a Titans’ run defense that has allowed over 300 rushing yards in two games. The Titans’ defensive struggles make them vulnerable, and this could present an opportunity for the Colts to extend their winning streak.
Key Players and Game Predictions
The Colts’ quarterback, Daniel Jones, has delivered strong performances in the first two games and is anticipated to continue leading the offense. Meanwhile, the spread for the game currently favors the Colts at -3.5 points. Experts have offered mixed predictions regarding the outcome, but the general expectation is that the Colts will aim to capitalize on the Titans’ current vulnerabilities.
Broadcast Information and Viewing Options
The game will be televised on CBS, with Tom McCarthy handling play-by-play, Ross Tucker providing analysis, and Amanda Balionis reporting from the sideline. Fans who want to follow the game can stream it through platforms like NFL+, Paramount+, YouTube TV, and Fubo, offering multiple options to watch the action live.
Summary
As the Indianapolis Colts look to extend their undefeated start, they face a Tennessee Titans team eager for their first victory despite injuries hampering key players. The game in Nashville is shaping up to be a pivotal early-season clash with both teams aiming to establish momentum and improve their standings in the AFC South.
Deeper Dive: News & Info About This Topic
HERE Resources
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Denver Broncos Narrowly Lose to Colts Amidst Controversial Call
Colts Secure Narrow Victory Over Broncos in Last-Second Thriller
Colts and Titans Clash in Key NFL Divisional Matchup
Colts Secure Narrow Victory with Last-Second Field Goal
Colts Edge Out Broncos in Controversial Close Finish
Colts Face Key Defensive Absences Ahead of Week 2 Matchup
Denver Broncos Gear Up for Clash with Indianapolis Colts
Broncos Face Colts in Key Week 2 NFL Matchup
Broncos Set to Clash with Colts in Week 2 Showdown
Additional Resources
- Indy Star: Indianapolis Colts Injury Report
- SI: Colts OL Admits Purposeful Penalty
- USA Today: NFL Colts vs Titans Predictions
- Google Search: Indianapolis Colts NFL
- Wikipedia: Indianapolis Colts

Author: STAFF HERE INDIANAPOLIS WRITER
The INDIANAPOLIS STAFF WRITER represents the experienced team at HEREIndianapolis.com, your go-to source for actionable local news and information in Indianapolis, Marion County, and beyond. Specializing in "news you can use," we cover essential topics like product reviews for personal and business needs, local business directories, politics, real estate trends, neighborhood insights, and state news affecting the area—with deep expertise drawn from years of dedicated reporting and strong community input, including local press releases and business updates. We deliver top reporting on high-value events such as the Indianapolis 500, Indy Jazz Fest, and the Indiana State Fair. Our coverage extends to key organizations like the Indy Chamber and Visit Indy, plus leading businesses in motorsports and healthcare that power the local economy such as Indianapolis Motor Speedway and IU Health. As part of the broader HERE network, we provide comprehensive, credible insights into Indiana's dynamic landscape.


